Dr Sharifah Nabihah Syed Jaafar
This project will study the surface modifications of electro-sprayed PCL microspheres to improve their hydrophobic properties through chemical modifications.
Partnering Australian Institution: University of Melbourne
Project Title: Improved polycaprolactone microspheres for cell culturing
Even though polymer microspheres such as polycaprolactone (PCL) has been widely used in cell culture, it shows a poor cell adhesion and consequently eliminate proliferation. This is because of different polarity between cell (hydrophilic) and PCL microspheres (hydrophobic). Hydrophobicity of the microspheres influence its biocompatibility properties. This deficit may solve by undergoes surface modification of PCL microsphere. As reported in previous study, PCL microspheres have been modified with protein, peptide and plasma. The modification promotes to cell growth on the microspheres and proliferate effectively. However, this approaches consider as expensive and complicated. Chemical surface modifications may improve the hydrophobic properties of PCL microspheres by undergone hydrolysis and impregnation with using formic acid (HCOOH) and arginylglycylaspartic acid (RGD) respectively. Thus, we propose to study the surface modifications of electro-sprayed PCL microspheres to improve their hydrophobic properties through chemical modifications.
Reasons for applying for fellowship:
International research and collaboration allow me to explore and exchange knowledge for better understanding on the latest theories and techniques on the field can be obtained. Besides, I am able to gain experience working with different environment and culture. This opportunity exposes me to the best practise on research management especially in facilities, postgraduate student/post doctorate fellow, writing a research grant/scientific paper etc. This is also an occasion to familiarize with good practices for my personal development as well as my home University in Malaysia. I embark on my own career as a competent and well known researcher.